Hilla Weidberg, Assistant Professor

Cell & Developmental Biology Research Group

Massachusetts Institute of Technology (Postdoc)
The Weizmann Institute of Science (PhD)
Tel Aviv University (BSc, MSc)

Office:  3.455 Phone: 604-827-6293
E-mail:  hilla.weidberg@ubc.caLab Website:  https://www.weidberglab.com/

R e s e a r c h   I n t e r e s t
Mitochondria are organelles that serve as a hub for cellular signaling and the biogenesis of indispensable metabolites. We aim to understand how mitochondrial homeostasis is maintained under challenging physiological and disease conditions. We focus on stress caused by perturbations in mitochondrial protein import which is associated with multiple human disorders as well as with aging and neurodegenerative diseases.
S e l e c t e d   P u b l i c a t i o n s
  1. Weidberg H, Amon, A. (2018) MitoCPR—A surveillance pathway that protects mitochondria in response to protein import stress. Science eaan4146 360.
  2. Rapaport D, Fichtman B, Weidberg H, Sprecher E, Horowitz M. (2018) NEK3-mediated SNAP29 phosphorylation modulates its membrane association and SNARE fusion dependent processes. Biochem Biophys Res Commun. 497(2):605-611.
  3. Weidberg H, Moretto F, Spedale G, Amon A, J. van Werven F. (2016) Nutrient control of yeast gametogenesis is mediated by TORC1, PKA and energy availability. PLoS Genet. 12(6).
  4. Pekar O, Benjamin S, Weidberg H, Smaldone S, Ramirez F, Horowitz M. (2012) EHD2 shuttles to the nucleus and represses transcription. Biochem J. 444, 383-94.
  5. Weidberg H, Shpilka T, Shvets E, Abada Adi, Shimron F, Elazar Z. (2011) LC3 and GATE-16 N-termini mediate membrane fusion processes required for autophagosome biogenesis. Dev Cell, 20, 444-54.
  6. Weidberg H, Shvets E, Elazar, Z. (2011) Biogenesis and cargo selectivity of autophagosomes. Ann Rev Biochem, 80, 125-56.
  7. Shvets E, Abada A, Weidberg H, Elazar Z. (2011) Dissecting the involvement of LC3B and GATE-16 in p62 recruitment into autophagosomes. Autophagy, 7, 683-8.
  8. Weidberg H, Elazar Z. (2011) TBK1 mediates cross-talk between the innate immune response and autophagy. Sci Signal, 4.
  9. Shpilka T, Weidberg H, Pietrokovski S, Elazar Z. (2011) Atg8, an autophagic-related ubiquitin-like protein family. Genome Biol, 12, 226.
  10. Benjamin S, Weidberg H, Rapaport D, Pekar O, Nudelman M, Segal D, Hirschberg K, Katzav S, Ehrlich M, Horowitz M. (2011) EHD2 mediates trafficking from the plasma membrane by modulating Rac1 activity. Biochem J., 439, 433-42.
  11. Weidberg H, Shpilka T, Shvets E, Elazar Z. (2010) Mammalian Atg8s: one is simply not enough. Autophagy 6, 808-9.
  12. Weidberg H, Shvets E, Shpilka T, Shimron F, Shinder V, Elazar Z. (2010) LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis. Embo J, 29, 1792-802.
  13. Scherz-Shouval R, Weidberg H, Gonen C, Wilder S, Elazar Z, Oren M. (2010) p53-dependent regulation of autophagy provides cancer cells with a survival advantage under prolonged starvation. PNAS, 43, 18511-6.
  14. Weidberg H, Shvets E, Elazar Z. (2009) Lipophagy: selective catabolism designed for lipids. Dev Cell, 16, 628-30.