Moukhles

Hakima Moukhles, Associate Professor

PostDoc – McGill University
PostDoc – University of Montreal
PhD – University of Aix Marseille II, France
MSc – University of Aix Marseille II, France
BSc – University Mohamed V, Rabat, Morocco

Office: 604-822-7882, Students: 604-827-5835
E-mail: hakima.moukhles@ubc.ca

R e s e a r c h I n t e r e s t s
Cellular and Molecular Neurobiology.

Dr. Moukhles’ lab focuses on the role of the dystroglycan multiprotein complex and its interaction with the extracellular matrix in the targeting and polarization of the water-permeable channel, aquaporin 4 to specialized membrane domains in astrocytes. Using a multidisciplinary approach applied to both in vitro and in vivo models, we are studying the mechanisms underlying aquaporin 4 localization in physiological and pathophysiological conditions including stroke.

R e c e n t P u b l i c a t i o n s
  1. The Laminin-Induced Phosphorylation of PKCδ Regulates AQP4 Distribution and Water Permeability in Rat Astrocytes  (2021) G Noël, DKL Tham, E Guadagno B MacVicar, H Moukhles, Cell Mol Neurobiol 41, 1743–1757
  2. Agrin plays a major role in the coalescence of the aquaporin-4 clusters induced by gamma-1-containing laminin (2019) G Noël, DKL Tham, BA MacVicar, H Moukhles, https://doi.org/10.1002/cne.24763
  3. The Oxidative Stress-Induced Increase in the Membrane Expression of the Water-Permeable Channel Aquaporin-4 in Astrocytes Is Regulated by Caveolin-1 Phosphorylation (2017) B Chongshan, DKL Tham, C Perronnet, B Joshi, IR Nabi, H Moukhles, Front. Cell. Neurosci., 20 https://doi.org/10.3389/fncel.2017.00412
  4. Determining Cell-surface Expression and Endocytic Rate of Proteins in Primary Astrocyte Cultures Using Biotinylation (2017) DKL Tham, H Moukhles, Tham, (125), e55974, doi:10.3791/55974
  5. Aquaporin-4 Cell-Surface Expression and Turnover Are Regulated by Dystroglycan, Dynamin, and the Extracellular Matrix in Astrocytes (2016) DKL Tham, B Joshi, H Moukhles, PLOS ONE 11(10): e0165439. https://doi.org/10.1371/journal.pone.0165439
Further publications can be found here.