Mark S. Cembrowski, Assistant Professor

UBC Investigator, Centre for Brain Health, UBC
Visiting Scientist, Janelia Research Campus, Howard Hughes Medical Institute
Next Generation Leader, Allen Institute for Brain Science

Janelia Research Campus, Howard Hughes Medical Institute (Postdoc)
Northwestern University (MS, PhD in Applied Mathematics)
University of British Columbia (BSc in Mathematics)

Office: 3.353,RA Office: 3.351
Office Phone: 604-822-3463
E-mail: mark.cembrowski@ubc.ca
Website: www.cembrowskilab.com

R e s e a r c h   I n t e r e s t
We aim to understand how the brain forms, stores, and retrieves memories. To do this, we take a multidisciplinary, multiscale approach. We combine big data analysis and cutting-edge experimental techniques to study memory across the spatial scales of the nervous system: molecules, cells, circuits, and behaviour. With this combination, we aim to generate a comprehensive understanding of the neurobiological rules of memory in both health and disorder.
P u b l i c a t i o n s
Selected publications (*: co-first, #: corresponding):

  1. Cembrowski, M.S.#, Spruston, N.# Pyramidal cell diversity within and across the fields of the hippocampus. Nature Reviews Neuroscience, in review (invited submission).
  2. Cembrowski, M.S. #, Wang, L., Lemire, A., DiLisio, S.F., Copeland, M., Clements, J., Spruston, N. The subiculum is a patchwork of discrete subregions. eLife, in press.
  3. Cembrowski, M.S.#, Phillips, M.G., DiLisio, S.F., Shields, B.C., Winnubst, J., Chandrashekar, J., Bas, E., Spruston, N. # Dissociable structural and functional hippocampal outputs via distinct subiculum cell classes. Cell 173(5): 1280–1292, 2018.
  4. Bloss, E.B., Cembrowski, M.S., Karsh, B., Colonell, J., Fetter, R.D., Spruston, N. # Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites. Nature Neuroscience 21(3): 353-363, 2018.
  5. Cembrowski M.S.#, Menon, V.# Continuous variation within cell types of the nervous system. Trends in Neurosciences 41(6): 339-350, 2018.
  6. Cembrowski, M.S. #, Spruston, N. Integrating results across methodologies is essential for producing robust neuronal taxonomies. Neuron 94(1): 747-751, 2017.
  7. Cembrowski, M.S.#, Spruston, N. Illuminating the neuronal architecture underlying context in fear memory. Cell 167(4): 888-889, 2016.
  8. Cembrowski, M.S., Wang., L., Sugino, K., Shields, B.C., Spruston, N. # Hipposeq: a comprehensive RNA-seq database of gene expression in hippocampal principal neurons. eLife 5, 10.7554/eLife.14997, 2016.
  9. Bloss, E.B., Cembrowski, M.S., Karsh, B., Colonell, J., Fetter, R., Spruston, N. # Structured patterns of dendritic inhibition support branch-specific forms of integration in CA1 pyramidal cells. Neuron 89(5): 1016-1030, 2016.
  10. Cembrowski, M.S., Bachman, J.L., Wang, L., Sugino, K., Shields, B.C., Spruston, N. # Spatial gene-expression gradients underlie prominent heterogeneity of CA1 pyramidal neurons. Neuron 89(2): 351-368, 2016.
  11. Kim, Y.*, Hsu, C.-L.*, Cembrowski, M.S., Mensh, B.D., Spruston, N. # Dendritic sodium spikes are required for long-term potentiation at distal synapses on hippocampal pyramidal neurons. eLife 4, doi:10.7554/eLife.06414, 2015.
  12. Choi, H., Lei, Zhang, L., Cembrowski, M.S., Sabottke, C.F., Markowitz, A.L., Butts, D.A., Kath, W.L., Singer, J.H., Riecke, H. # Intrinsic bursting of AII amacrine cells underlies oscillations in the rd1 mouse retina. Journal of Neurophysiology 112(6): 1491-1504, 2014.
  13. Ke, J., Wang, Y., Borghuis, B.G., Cembrowski, M.S., Riecke, H., Kath, W.L., Demb, J.B., Singer, J.H. # Adaptation to background light enables contrast coding at rod bipolar cell synapses. Neuron 81(2): 388-401, 2014.
  14. Cembrowski, M.S. #, Logan, S., Tian, M., Jia, L., Li, W., Kath, W.L., Riecke, H., Singer, J.H. The mechanisms of repetitive spike generation in an axonless retinal interneuron. Cell Reports 1(2): 155-166, 2012.
  15. Jarsky, T.*, Cembrowski, M.S.*, Logan, S., Kath, W.L., Riecke, H., Demb, J., Singer, J.H. # A synaptic mechanism for retinal adaptation to luminance and contrast. The Journal of Neuroscience 31(30): 11003-110515, 2011.