Research Interests

Dr. Rideout’s research program is focused on identifying metabolic genes and pathways that contribute to sex differences in metabolism and metabolic disease. Major areas of research in Dr. Rideout’s lab concern (1) sex differences in insulin production under normal conditions and during stress using fly, rodent and human models; (2) sex differences in the regulation of body fat throughout the life course using the fly as a model; (3) understanding how sex determination factors contribute to male-female differences in development and physiology. Dr. Rideout and lab members are grateful for the privilege of working on the traditional, ancestral, and unceded territory of the xwməθkwəy̓əm (Musqueam) people.

  1. Rideout, E.J., Narsaiya, M.S., Grewal, S.S. (2015) The sex determination gene transformer regulates male-female differences in Drosophila body size. PLoS Genetics. 11, e10005683.
  2. Wat, L.W., Chao, C., Bartlett, R., Buchanan, J., Millington, J.W., Chih, T., Chowdhury, Z., Biswas, P., Huang, V., Shin, L., Wang, L., Gauthier, M.P., Barrone, C., Montooth, K., Welte, M., Rideout, E.J. (2020) A role for triglyceride lipase brummer in the regulation of sex differences in Drosophila fat storage and breakdown. PLoS Biology. 18, e3000595.
  3. Millington, J.W., Brownrigg, G.P., Basner-Collins, P.J., Sun, Z.., Rideout, E.J. (2021) Genetic manipulation of insulin/insulin-like growth factor signaling pathway activity has sex-biased effects on Drosophila body size. G3: Genes, Genomes, Genetics. 11, jkaa067.
  4. Millington, J.W., Chao, C., Sun, Z., Basner-Collins, P.J., Brownrigg, G.P., Wat, L.W., Hudry, B., Miguel-Aliaga, I., Rideout, E.J. (2021) Female-biased upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity. eLife. 10, e58341.
  5. Wat, L.W., Chowdhury, Z.S., Millington, J.W., Biswas, P., Rideout, E.J. (2021) Sex determination gene transformer regulates the male-female difference in Drosophila fat storage via the adipokinetic hormone pathway. eLife. 10, e72350.
  6. Skovsø, S., Panzhinskiy, E., Kolic, J., Dionne, D.A., Dai, X.Q., Sharma, R.B., Elghazi, L., Cen H.H., Ellis, C.E., Faulkner, K., Marcil, S.A.M., Overby, P., Noursadeghi, N., Hutchinson, D., Hu, X., Li, H., Modi, H., Wildi, J., Botezelli, J.D., Noh, H.L., Suk, S., Gablaski, B., Bautista, A., Kim, R.K., Cras-Méneur, C., Flibotte, S., Sinha, S., Luciani, D.S., Nislow, C., Rideout, E.J., Cytrynbaum, E.N., Kim, J., Bernal-Mizrachi, E., Alonso, L.C., MacDonald, P.E., Johnson, J.D. (2022) Beta-cell specific insulin resistance promotes glucose-stimulated insulin hypersecretion. Nature Communications. 13, 735.
  7. Millington, J.W., Biswas, P.B. , Chao, C.F., Xia, Y.H., Wat, L.W., Brownrigg, G.P., Sun, Z., Basner-Collins, P.J., Klein Geltink, R.I., Rideout, E.J. (2022) A low sugar diet enhances Drosophila body size in males and females via sex-specific mechanisms. Development. 149, dev200491.
  8. Zhang, A.M.Y., Chu, K.H., Daly, B.F., Ruiter, T., Dou, Y., Yang, J.C.C., de Winter, T.J.J., Chhuor, J., Wang, S., Flibotte, S., Zhao, Y., Hu, X., Li, H., Rideout, E.J., Schaeffer, D.F., Johnson, J.D., Kopp, J.L. (2022) Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics. Cancer & Metabolism. 10, 5.
  9. Brownrigg, G.P., Xia, Y.H., Chu, C.M.J., Wang, S., Chao, C.F., Zhang, J.A., Skovso, S., Panzhinskiy, E., Hu, X., Johnson, J.D. §, Rideout, E.J. § (2023) Sex differences in islet stress responses support female beta cell resilience. Molecular Metabolism. 69, 101678.
  10. Zhang, A.M.Y., Xia, Y.H., Lin, J.S.H., Chu, K.H., Ruiter, T.J.J., Yang, J.C.C., Chen, N., Chhuor, J., Patil, S., Cen, H.H., Rideout, E.J., Richard, V.R., Schaeffer, D.F., Zahedi, R.P., Borchers, C.H., Johnson, J.D., Kopp, J.L. (2023) Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics. Cell Metabolism. 35, 2119-2135.
  11. Chao, C.F., Pesch, Y.Y., Yu, H., Wang, C., Aristizabal, M., Huan, T., Tanentzapf, G., Rideout, E.J. (2023) An important role for triglyceride in regulating spermatogenesis. eLife. 12, RP87523.
  12. Fleck, S.A., Biswas, P., DeWitt, E.D., Knuteson, R.L., Eisman, R.C., Nemkov, T., D’Alessandro, A., Tennessen, J.M., Rideout, E.J., Weaver, L.N. (2023) Auxin exposure disrupts feeding behavior and fatty acid metabolism in adult Drosophila. eLife. 12, RP91953.
  13. Cherian, C., Reeves, H., Da Silva, D., Tsao, S., Marshall, K.E., Rideout, E.J. (2024) Consideration of sex as a biological variable in diabetes research across twenty years. Biology of Sex Differences. 15, 19.
  14. Millington, J.W. & Rideout, E.J. (2018) Sex differences in Drosophila development and physiology. Current Opinion in Physiology. 6, 46-56.
  15. Millington, J.W. & Rideout, E.J. (2020) Sexual dimorphism: Ecdysone modulates sex differences in the gut. Current Biology. 30, R1327-1330.
  16. Mank, J.E. & Rideout, E.J. (2021) Developmental mechanisms of sex differences: from cells to organisms. Development. 148, dev199750.
Further publications can be found here.