Moukhles

Hakima Moukhles, Associate Professor

PostDoc – McGill University
PostDoc – University of Montreal
PhD – University of Aix Marseille II, France
MSc – University of Aix Marseille II, France
BSc – University Mohamed V, Rabat, Morocco

Office: 604-822-7882, Students: 604-827-5835
E-mail: hakima.moukhles@ubc.ca

R e s e a r c h I n t e r e s t s

Cellular and Molecular Neurobiology.

Dr. Moukhles’ lab focuses on the role of the dystroglycan multiprotein complex and its interaction with the extracellular matrix in the targeting and polarization of the water-permeable channel, aquaporin 4 to specialized membrane domains in astrocytes. Using a multidisciplinary approach applied to both in vitro and in vivo models, we are studying the mechanisms underlying aquaporin 4 localization in physiological and pathophysiological conditions including stroke.

R e c e n t P u b l i c a t i o n s
  1. Tham DKL, Moukhles H*. (2011) Regulation of Kir4.1 and AQP4 expression and stability at the basolateral domain of epithelial MDCK cells by the extracellular matrix. American Journal of Physiology: Renal Physiology 301(2):F396-409. [IF 91].
  2. Noël G, Stevenson S, Moukhles H*. (2011) A High Throughput Screen Identifies Chemical Modulators of the Laminin-induced Clustering of Dystroglycan and Aquaporin-4 in Primary Astrocyte Cultures. PLoS One 6:e17559. [IF 41].
  3. Lui L, Levinson JN, Noël G, Handrigan GR, Richman JM, El-Husseini A, Moukhles H*. (2010) Synaptic Localization of Neuroligin 2 in the Rodent Retina: a Comparative Study with the Dystroglycan-Containing Complex. J Neuroscience Research 88:837–849. [IF 2].
  4. Noël G, Tham D, Moukhles H*. (2009) Interdependence of laminin-mediated clustering of lipid rafts and the dystrophin complex in astrocytes. J Biol Chem 284(29):19694-704. [IF 4].
Further publications can be found here.