The research in my laboratory is directed towards the investigation of gastrointestinal functions of peptides such as substance P, neurokinins and endothelins; studies include the investigation of the control of release of these peptides, and the effects these peptides have on gastric and pancreatic endocrine secretion, gastric acid secretion, gastrointestinal motility and neurotransmitter release in the peripheral and enteric nervous system. The localization, distribution and classification of these peptide receptors are also studied using autoradiographic and radioligand binding techniques. The cholinergic and purinergic mechanism in the gastrointestinal tract are also studied. These include investigation of the actions of adenosine and its analogues, the regulation of the acetylcholine release and synthesis, as well as the distribution and localization of cholinergic and purinergic receptors. The peptidergic, cholinergic and purinergic mechanisms under pathophysio-logical states, such as diabetes and gastrointestinal ulcerative formations, are also studied.

Purinergic mechanisms in the gastrointestinal tract (receptor identification and localization; second messenger systems; biological actions; neurotransmission)

Neurotrophic factors in the gastrointestinal tract and the urinary bladder (neurotrophins; receptor identification and localization; biological actions)

Mechanisms in neurodegenerative diseases (Parkinsonism; dyskinesia; regulatory peptides)

  1. Yang GK, Fredholm BB, Kieffer TJKwok YN*. (2012) Improved blood glucose disposal and altered insulin secretion patterns in adenosine A1 receptor knockout mice. J. Physiol. Endocrinol. Metab 303: E190-E180. [IF 4.51].
  2. Yang GK, Squires PE, Tian TF, Kieffer TJKwok YN, Dale N. (2012) Glucose decreases extracellular adenosine levels in isolated mouse and rat pancreatic isletsIslets 4: 46-70. [IF 1.54].
  3. Yang GK, Yip L, Fredholm BB, Kieffer TJ, Kwok YN*. (2011) Involvement of adenosine signaling in controlling the release of ghrelin from the mouse stomach. Pharmacol. Exp. Ther 336: 77-86[IF 3.83].
  4. Yang GK, Chen JF, Kieffer TJ, Kwok YN*. (2009) Regulation of somatostatin release by adenosine in the mouse stomach. J. Pharmacol. Exp. Ther 329: 729-737. [IF 4.09].
Further publications can be found here.