Ryan Hoiland
Assistant Professor
Faculty of Medicine Southern Medical Program (SMP)
Investigator within the Centre for Chronic Disease Prevention and Management (CCDPM)
Postdoc, University of British Columbia (2018-2023)
PhD, University of British Columbia (2015-2018)
MSc, University of British Columbia (2013-2015)
BHk, University of British Columbia (2009-2013)
Email: ryan.hoiland@ubc.ca
Dr. Hoiland completed his PhD (2015-2018) at the University of British Columbia Okanagan, where he studied cerebrovascular physiology and human adaptation to hypoxia. As a postdoctoral fellow, Dr. Hoiland investigated the pathophysiology of hypoxic-ischemic brain injury as well as traumatic spinal cord injury, with a focus on mitigating secondary hypoxic injury. Collectively, his training involved studying how the central nervous system responds to hypoxia in pre-clinical disease models, healthy humans, and patients.
Our laboratory aims to determine neuroprotective strategies to improve outcomes for patients suffering an acute central nervous system injury. We conduct studies across the translational continuum in pre-clinical disease models, healthy human studies, and clinical patient studies to characterize the pathophysiology of acute traumatic and/or ischemic central nervous system injury. This includes a focus on determining how we can optimize oxygen delivery to the brain and spinal cord following an acute injury, with a further interest in cerebrovascular regulation as it pertains to health, disease, and adaptions to stressors such as exercise and the environment.
Hoiland RL, Robba C, Menon DK, Citerio G, Sandroni C, Sekhon MS. Clinical targeting of the cerebral oxygen cascade to improve brain oxygenation in patients with hypoxic-ischaemic brain injury after cardiac arrest. Intensive Care Med. 2023 Sep;49(9):1062-1078. doi: 10.1007/s00134-023-07165-x. PMID: 37507572
Hoiland RL, MacLeod DB, Stacey BS, Caldwell HG, Howe CA, Nowak-Flück D, Carr JM, Tymko MM, Coombs GB, Patrician A, Tremblay JC, Van Mierlo M, Gasho C, Stembridge M, Sekhon MS, Bailey DM, Ainslie PN. Hemoglobin and cerebral hypoxic vasodilation in humans: Evidence for nitric oxide-dependent and S-nitrosothiol mediated signal transduction. J Cereb Blood Flow Metab. 2023 Sep;43(9):1519-1531. doi: 10.1177/0271678X231169579. PMID: 37042194
Hoiland RL, Rikhraj KJK, Thiara S, Fordyce C, Kramer AH, Skrifvars MB, Wellington CL, Griesdale DE, Fergusson NA, Sekhon MS. Neurologic Prognostication After Cardiac Arrest Using Brain Biomarkers: A Systematic Review and Meta-analysis. JAMA Neurol. 2022 Apr 1;79(4):390-398. doi: 10.1001/jamaneurol.2021.5598. PMID: 35226054.
Hoiland RL, Caldwell HG, Carr JMJR, Howe CA, Stacey BS, Dawkins T, Wakeham DJ, Tremblay JC, Tymko MM, Patrician A, Smith KJ, Sekhon MS, MacLeod DB, Green DJ, Bailey DM, Ainslie PN. Nitric oxide contributes to cerebrovascular shear-mediated dilatation but not steady-state cerebrovascular reactivity to carbon dioxide. J Physiol. 2022 Mar;600(6):1385-1403. doi: 10.1113/JP282427. PMID: 34904229.
Hoiland RL, Ainslie PN, Wellington CL, Cooper J, Stukas S, Thiara S, Foster D, Fergusson NA, Conway EM, Menon DK, Gooderham P, Hirsch-Reinshagen V, Griesdale DE, Sekhon MS. Brain
Hypoxia Is Associated With Neuroglial Injury in Humans Post-Cardiac Arrest. Circ Res. 2021 Aug 20;129(5):583-597. doi: 10.1161/CIRCRESAHA.121.319157. PMID: 34287000.
Further publications can be found here.
Interested in joining us? The laboratory is currently looking for graduate students and postdoctoral fellows. Please email Dr. Hoiland with your CV attached.