Brett Hilton
Principal Investigator, International Collaboration on Repair Discoveries (ICORD)
Blusson Spinal Cord Centre
Full Member, Djavad Mowafaghian Centre for Brain Health
German Centre for Neurodegenerative Diseases (DZNE, Postdoc)
University of British Columbia (PhD in Zoology)
University of British Columbia (BSc in Cell Biology & Genetics)
Emails: bhilton@icord.org
Website: www.hiltonlab.ca
We seek to develop neuroregenerative and neuroprotective therapies that enable meaningful functional improvements in individuals with spinal cord injury. We use a multidisciplinary research strategy combining cellular, molecular, and bioinformatic approaches together with tissue clearing and 3D imaging analyses in order to identify the processes that prevent damaged axons from regenerating. We are also interested in identifying the cells and circuits that are most important for mediating functional improvements after injury.
- I. Samad, B.J. Hilton (2025). Chromatin accessibility regulates axon regeneration. Neural Regeneration Research 21(4), 1548-1549.
- B.J. Hilton, J.M. Griffin, J.W. Fawcett, F. Bradke (2024). Neuronal maturation and axon regeneration: unfixing circuitry to enable repair. Nature Reviews Neuroscience 25, 649-667.
- B.J. Hilton, A. Husch, B. Schaffran, M. Schelski, T.C. Lin, C. Imig, B.H. Cooper, N. Brose, F. Bradke (2022). An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury. Neuron 110 (1), 51-69.
- Stern*, B.J. Hilton*, E. Burnside, S. Dupraz, E. Handley, J. Gonyer, C. Brakebusch, F. Bradke (2021). RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity following CNS injury. Neuron 109 (21), 3437-3456. *Co-First Author.
- B.J. Hilton, O. Blanquie, A. Tedeschi, F. Bradke (2019). High resolution 3D imaging and analysis of axon regeneration in unsectioned spinal cord with or without tissue clearing. Nature Protocols 14, 1235-1260.