The 13th D. Harold Copp Lecture-Towards a molecular logic of synaptic connections: Neurexins and their ligands

by Thomas Südhof, Professor, M.D., Ph.D

2013 Nobel Prize Winner in Physiology Howard Hughes Medical Institute
Dept. of Molecular and Cellular Physiology Stanford University School of Medicine

Neural circuits process information by transmitting and computing signals at synapses whose number, location, and properties determine the input/ output relations of a circuit. In his lecture, Thomas Südhof will describe his laboratory’s efforts to decipher the molecular code that determines the formation and speci cation of these synapses. His talk will focus on neurexins and their ligands as central regulators of synapse properties, and how neurexins might relate to other trans-synaptic regulators of synapse formation and properties. In addition, he will discuss the links of mutations in genes encoding neurexins and their ligands to neuropsychiatric disorders.