Guy Tanentzapf, Associate Professor

Post Doctoral Fellowship: Gurdon Institute, University of Cambridge
PhD: Department of Zoology, The University of Toronto
B.Sc. (Honours), Molecular Biology and Molecular Genetics, The University of Toronto

Telephone: 1.604.877.4334
Email : tanentz@mail.ubc.ca
Lab website: www.tanentzapf-lab.com
Lab Twitter: twitter.com/tanentzapflab

Version 2
About the Tanentzapf Lab
Our Lab is Interested in understanding how cell junctions contribute to animal development and to the regulation of stem cell behaviour.  Our primary interest is in answering question in developmental and cell biology. In particular we are interested in how animal tissues develop and maintain their complex three dimensional architecture. Our lab is multidiscplinary and uses approaches that span the fields of genetics, cell and developmental biology, quantitative high resolution imaging, biochemsitry and molecular biology, and systems biology.
R e c e n t P u b l i c a t i o n s
  1. Hákonardóttir GK1, López-Ceballos P1, Herrera-Reyes AD2, Das R3, Coombs D2, Tanentzapf G4. (2015)  In Vivo Quantitative Analysis of Talin turnover in response to force.Mol Biol Cell. In press.
  2. Smendziuk CM1, Messenberg A1, Vogl AW1, Tanentzapf G2.(2015) Bi-directional gap junction-mediated soma-germline communication is essential for spermatogenesis. Development. 2015 Aug 1;142(15):2598-609.
  3. Fairchild MJ, Smendziuk CM, Tanentzapf G*. (2015) A somatic permeability barrier around the germline is essential for Drosophila spermatogenesis. Development 142(2):268-81. [IF 6.7].
  4. Cetera M, Ramirez-San Juan GR, Oakes PW, Lewellyn L, Fairchild MJ, Tanentzapf G*, Gardel ML, Horne-Badovinac S. (2014) Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation. Nat Communications 5:5511. [IF 10.3].
  5. Ellis SJ, Lostchuck E, Goult BT, Bouaouina M, Fairchild MJ, López-Ceballos P, Calderwood DA, Tanentzapf G*.(2014) The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering. PLOS Genetics 10(11):e1004756. [IF 8.8].
  6. Perkins AD, Lee MJJ, Tanentzapf G*. (2014) The systematic identification of cytoskeletal genes required for Drosophila melanogaster muscle maintenance. Scientific Data. 1:140002.
  7. Perkins AD, Tanentzapf G*.(2014) An ongoing role for structural sarcomeric components in maintaining Drosophila melanogaster muscle function and structure. PLOS One 9(6):e99362. [IF 3.2].
  8. Ellis SJ, Goult BT, Fairchild MJ, Harris NJ, Long J, Czerniecki S, Lobo P, Van Petegem F, Schoeck F, Peifer M, Tanentzapf G*. (2013) Talin autoinhibition is required for morphogenesis. Current Biology 23:1825-1833. [IF 9.7].
  9. Bouaouina M, Jani K, Czerniecki S, Long JY, Ellis SJ, Tanentzapf G*, Calderwood DA, Schöck F. (2012) Zasp regulates integrin activation. Journal of Cell Science 123(23): 5647-57. [IF 6.7].
  10. Pines M, Das R, Ellis SJ, Morin A, Czerniecki S, Yuan L, Kluse M, Coombs D, Tanentzapf G*. (2012) Regulation of integrin turnover by force in vivo. Nature Cell Biology 14:935-943. [IF 19.6].
  11. Pines M, Fairchild MJ, Tanentzapf G*. (2011) Distinct regulatory mechanisms control integrin adhesive processes during tissue morphogenesis. Developmental Dynamics 240:36-51. [IF 3.0].
  12. Ribeiro I, Yuan L, Tanentzapf G*, Dowling JJ, Kiger A. (2011) Phosphoinositide regulation of integrin trafficking required for muscle attachment and maintenance. PloS Genetics 10:7(2):e1001295. [IF 8.8].
  13. Ellis SJ, Pines M., Fairchild M.J., Tanentzapf G*. (2011) In vivo functional analysis reveals specific roles for the integrin binding sites of talin. Journal of Cell Science 124:1844-1856. [IF 6.7].
  14. Franco-Cea A, Ellis SJ, Fairchild MJ, Yuan L, Cheung TY, Tanentzapf G*. (2010) Distinct developmental roles for direct and indirect talin-mediated linkage to actin. Developmental Biology 345:64-77. [IF 4.7].
  15. Perkins AD, Ellis SJ, Asghari P, Shamsian A, Moore ED, Tanentzapf G*. (2010) Integrin-mediated adhesion maintains the sarcomeric cytoarchitecture. Developmental Biology 338:15-27. [IF 4.7].
  16. Yuan L, Fairchild MJ, Perkins AD, Tanentzapf G*. (2010) Analysis of integrin turnover in fly myotendinous junctions. Journal of Cell Science 123:939-946. [IF 6.7].
  17. Cheung TY, Fairchild MJ, Zarivach R, Tanentzapf G*, Van Petegem F. (2009) Crystal Structure of the Talin Integrin Binding Domain 2. Journal of Molecular Biology 387:787-793. [IF01].
Further publications can be found here.