|R e s e a r c h I n t e r e s t s|
**The main focus of the lab is to understand how male-female differences in the regulation of growth and metabolism contribute to sex differences in body size, stress responses and lifespan**
Regulated growth is essential for attaining the correct cell, tissue and organismal size – too much or too little growth during development causes growth disorders. Even after development is complete, the regulation of growth is essential for tissue repair and replacement during the whole of an animal’s life. In this case, deregulated growth disrupts tissue homeostasis, leading to an increased risk of cancer, and/or shortened lifespan. Therefore, understanding the mechanisms that control cell, tissue and body growth is not only a fundamental question in biology, but has significant implications for health research.
An important determinant of growth in all animals is sex. Male-female differences in cell, tissue and body size are widespread in the animal kingdom. In addition, the incidence and progression of some forms of cancer show a strong sex bias. Yet how the regulation of growth differs between males and females to produce these differences in size and health outcomes remains unclear. In our lab, we use the fruit fly, Drosophila melanogaster, as a model to study the genetic, molecular and physiological mechanisms that control male-female differences in cell and body size.
Our studies have uncovered many parallels between the sex-specific regulation of growth in flies and in mammals. The focus of our research is to use the power of Drosophila genetics to identify pathways that are regulated by sex, and to investigate how this regulation affects growth. In doing so, we will identify new roles for many pathways in controlling sex differences in cell, tissue and body size. Since many of these pathways also play roles in stress responses and lifespan, studying how their regulation and function differs in males and females will provide insight into sex differences in stress survival and aging.
|S e l e c t e d P u b l i c a t i o n s|
1. Rideout, E.J. and Grewal, S.S. (2015) The sex determination gene transformer controls male-female differences in Drosophila body size (submitted)
2. Ghosh, A., Rideout, E.J., Grewal, S.S. (2014). TIF-IA-dependent regulation of ribosome synthesis in Drosophila muscle is required to maintain systemic insulin signaling and larval growth. PLoS Genet. 10, e1004750.
3. Marshall, L., Rideout, E.J., Grewal, S.S. (2012). Nutrition/TOR-dependent regulation of RNA polymerase III controls tissue and organismal growth in Drosophila. EMBO J. 31, 1916-30.
4. Rideout, E.J., Marshall, L., Grewal, S.S. (2012). Drosophila RNA polymerase III repressor Maf1 controls body size and developmental timing by modulating tRNAiMet synthesis and systemic insulin signaling. Proceedings of the National Academy of Science USA. 109, 1139-44.
5. Rideout, E.J., Dornan, A.J., Neville, M.C., Eadie, S., Goodwin, S.F. (2010). Control of sexual differentiation and behaviour by the doublesex gene in Drosophila melanogaster. Nature Neuroscience. 13, 458-66.
6. Aran, V., Brandie, F.M., Boyd, A.R., Kantidakis, T., Rideout, E.J., Kelly, S.M., Gould, G.W., Bryant, N.J. (2009). Characterization of two distinct binding modes between syntaxin 4 and Munc18c. Biochem. J. 419, 655-60.
7. Rideout, E.J. and Goodwin, S.F. (2008). Sexual dimorphism: can you smell the difference? Current Biology. 18, R425-7.
8. Rideout, E.J., Billeter, J.C., Goodwin, S.F. (2007). The sex-determination genes fruitless and doublesex specify a neural substrate required for courtship song. Current Biology. 17, 1473-8.
9. Billeter, J.C., Rideout, E.J., Dornan, A.J., Goodwin, S.F. (2006). Control of male sexual behaviour in Drosophila by the sex determination pathway. Current Biology. 16, R766-76.
Further publications can be found here.